The Best Product for Painful Sex Tested by Pelvic Radiation

Currently, three types of methods are used to treat painful sex. One type includes estrogen and its derivatives. The second type includes energy-based devices like MonaLisa Touch. NeuEve is a third type of method. It is a new type. It uses topical nutritional supplement to reverse vaginal atrophy like a wrinkle serum to reverse wrinkles (atrophy of the skin). There are also lubes and jellies, but these products are for easing symptoms only by providing lubrication or moisture. They do not treat the cause of painful sex – vaginal atrophy.

How these methods work?

Estrogen heals vaginal atrophy by binding to estrogen receptors to stimulate the growth of the atrophied vaginal tissue.

Estrogen receptor trigger gene activation

MonaLisa Touch heals vaginal atrophy by creating micro-wounds deep inside the tissue with a laser gun. The micro-wounds inside the tissue trigger a wound-healing event. The event stimulates growth factors to achieve reversal of vaginal atrophy.

The laser gun of MonaLisa Touch

NeuEve heals vaginal atrophy by nutritional supplements, like calcium and vitamin D for bones. Due to nutrients starvation, the vaginal tissue shrinks. Supplementing nutrients reverses this process.

How to compare these methods?

With an easy problem, it would be difficult to compare different methods because all can solve an easy problem.

However, with a difficult problem, only the best method can solve it. Mediocre methods cannot.

It is like high jump. Everybody can jump over a low bar, but only a professional high jumper can jump over a 2-meter-high bar.

A high bar can separate a good from mediocre jumpers.

Therefore, to identify which method is better for vaginal atrophy relief, we need to find the most severe type of vaginal atrophy to set the bar high.

What causes the most severe vaginal atrophy?

Normally, vaginal atrophy is not a disease, but an aging outcome. When women get older, especially after menopause, their vaginal tissue gradually becomes atrophic.

But cancer treatments can cause an early onset of vaginal atrophy to accelerate the aging process. In some cases, cancer treatments can cause very severe vaginal atrophy. These treatments include chemotherapy for any cancer, antiestrogen therapy for breast cancer, and pelvic radiation therapy for cancer in the pelvis.  

Chemotherapy and antiestrogen therapy shrink vaginal tissue by inhibiting cell growth. They do not cause physical injuries. This type of atrophy is like the atrophy caused by menopause. Many treatment methods can reverse this type of atrophy. Therefore, it is a mild form of vaginal atrophy.

However, pelvic radiation is different. The radiation energy kills cancer cells by damaging their DNA. Cancer cells with DNA damages stop dividing and die. A problem of radiation therapy is collateral damages to adjacent tissues. One of such damages is a severe type of vaginal atrophy.

This type is different from vaginal atrophy caused by menopause. It not only inhibits tissue growth, but also causes physical injuries.

Pelvic radiation causes the most severe vaginal atrophy

Who receive pelvic radiation?

Women with the following cancers may receive pelvic radiation:

  • Cervical cancer
  • Womb (endometrial) cancer
  • Vaginal cancer
  • Vulval cancer
  • Bladder cancer
  • Rectal cancer
  • Anal cancer
  • Lymphoma in the pelvic area

Which product relieves the most severe vaginal atrophy?

Menopause-induced atrophy is caused by estrogen reduction. Supplementing estrogen can reverse it.

Theoretically, estrogen can relieve vaginal atrophy induced by chemotherapy or antiestrogen therapy. However, due to its cancer risk, women who had chemotherapy or antiestrogen therapy do not wish to use estrogen for treatment of vaginal atrophy. They often seek alternative methods.

Female colon cancer survivors can use estrogen because colon cancer is not sensitive to estrogen. However, their severe vaginal atrophy caused by pelvic radiation for treating colon cancer is not relieved by estrogen. No effect at all. Radiation-induced vaginal atrophy is caused by physical tissue damages of radiation, not by estrogen reduction. Supplementing estrogen does not reverse this type of atrophy. Due to its ineffectiveness and cancer risk, estrogen is not recommended for use by women with pelvic radiation.

How about Mona Lisa Touch? Many women with previous pelvic radiation tried it, but they reported that Mona Lisa Touch did not provide any relief. Due to its ineffectiveness, having a history of pelvic radiation is on the list of contraindications of MonaLisa Touch website. This means that women with a history of pelvic radiation will be excluded from treatment by MonaLisa Touch.

How about NeuEve? After trying NeuEve Balm Cream and Silk suppositories, many women with previous pelvic radiation reported that they had found rapid and effective relief.

NeuEve is the best product to heal vaginal atrophy caused by pelvic radiation

NeuEve – The only product relieves radiation-induced atrophy

Many women with pelvic radiation have tried all available products on the market for vaginal atrophy relief, but all had failed. After trying NeuEve, they said that NeuEve is the only product that helped them to find relief.

Therefore, by comparison with estrogen and MonaLisa Touch on the same women with the most severe type of vaginal atrophy, NeuEve won. 

Doctors and women’s health nurse practitioners at the Massachusetts General Hospital of Harvard are recommending NeuEve to their pelvic radiation patients.

Since NeuEve has passed the test by relieving the most severe type of vaginal atrophy, it is the best product for relieving vaginal dryness and painful sex in all women, not just for women with pelvic radiation. It works better than estrogen and MonaLisa Touch. It is much safer and costs much less.

Say “Goodbye” to painful sex for good with NeuEve!

Disclaimer: This article is for information purposes only. It is about natural products, nutrients, and/or methods for managing vaginal aging-related discomfort (not a true infection or disease). It is not medical advice for the treatment of any diseases.


Customer review on pelvic radiation-related or after estrogen had failed


Reviewed in the United States on February 7, 2017

I am a young cancer survivor that was forced into menopause early from my cancer treatments. This is the only product that has worked long term for me.

I struggled with BV issues for some time and obviously vaginal atrophy from pelvic radiation, since using this product I have not had one single reoccurrence of BV. I have since recommended this product to a few of my friends all of whom are either pre-or post-menopausal with similar issues (odd odor, less natural lubrication) and they all seem to love it and recommend it.

I would say initially I was skeptical; I have been using this for about 6 months and my honest opinion is that this product is exactly what the packaging states. Please keep in mind I produce no natural hormones and have been in hormone replacement therapy for 5 years, nothing has worked as well as this product. It is safe, effective, and works quickly.

Amazon Customer

Surviving Radiation Therapy with NeuEve

Reviewed in the United States on May 5, 2015

“Thank you, Dr. Chang. And thank you for the greatest product ever. I had uterine cancer and underwent radiation therapy. NeuEve has been a life-changer.”


Breast cancer survivors love NeuEve.

“I just had to tell you, please let the amazing doctor who developed this product know that it has truly changed my life. Breast cancer with chemo, then forced oophorectomy (darn ovaries would not stop making estrogen and I can’t take tamoxifen), and now anastrozole. This caused severe vaginal atrophy and very painful sex. I tried Mona Lisa Touch which worked so so and only temporarily, and ThermiVa which did nothing. Your product has changed the tissue and dramatically decreased the pain. I have to stick with Level 1 though because Level 2 doesn’t work as well. I have shared NeuEve with many friends and it has changed their lives too!! Thank you!!”


NeuEve Gold

Effect proved by a gynecologist doctor

This is a fabulous product that works better than any hormone based suppository and without the risks. My Gynecologist has tracked my progress over a three month period and is now telling other patients to give it a try.

Woman with a total hysterectomy

NeuEve vs. estrogen, side-by-side competition. Guess who won?

Amazing Real Results

I am 50 yr old and had a total hysterectomy due to severe endometriosis. About 3 months on the nose, I attempted intimate relations with my husband and it was the worst pain ever… Even worst then my very first time. My doctor gave me estrogen tablets to insert into my vagina and I also purchased Silk suppositories. I added a few other oral supplements and sex was great. Little to no pain. I ran out of the suppository and only had been using estrogen. Tried sex again, and the severe pain was back. Just stocked up on two boxes of Silk, no more estrogen and again, no pain with sex at all!!! We didn’t even need lubricant. I am a customer for life.!! We did it 4 days straight!!! Hahaha…. Just being honest. That’s huge for us!!! Buy it!

NeuEve Silver

Great product
This product works! I’ve tried estrogen cream in the past. This works much better than the prescription hormone estrogen cream. I had dryness and burning and it all disappeared. I love the silver which works for me. Thank you for making such a wonderful product.

NeuEve Cream

Outstanding Product!
This is a miracle cream! After being on estrogen ointment for three months with no relief, I tried NeuEve. Within one week, I had relief from my symptoms. I highly recommend this product.

Melanie S.
NeuEve Silver

Excellent product
I am in my 10th year of post-menopause. Started having atrophy right away after menopause. Used estrogen cream for a while, until I realized it was harmful to me. Kind of “endured” the pain for years. Been on NeuEve for a year now and am thrilled to be almost atrophy-free. Highly recommend this product. Just wish it was cheaper.

NeuEve Silk

Now I can have a pap smear
My vaginal dryness is so severe that I am unable to have a pap smear. I tried estrogen vaginal cream but it aggravated my fibroid tumors and caused severe pain in my abdomen. After taking Nueve Silk Formula for a month I, now, feel confident that I can take the exam. It has also improved my sex life. My husband and I are now able to have intercourse, again, after going three years without it.

NeuEve Silk

I am 35 and am healing from an Autoimmune disorder. Along with Autoimmune came fertility issues. Vaginal Atrophy and low estrogen being one of them. I cannot use hormone-related products to help with the Atrophy, the hormones make my Thyroid levels drop immediately. So I researched and researched until I found this amazing product !!!! yay!!! My husband and I can have sex again…. We are seeing significant success after just 2 applications of the silk line. I plan on going through the whole lineup to GOLD !!!! Can’t thank this amazing company enough!!!! I Love y’all! PS. Please no offense taken ….. you should get a more modern look to your package … I had skipped over it many times in my research because it looks like a 1990 styled douche package that has been sitting at the Dollar Store for a while. The outside needs to match the amazing product!

NeuEve Cream

Really works
I had to go off of estriol vaginal cream since my estrogen levels went up too high. The cream alone is working really well, in some ways better than the estriol cream, I can feel the dryness is gone, and also the vagina seems really healthier. It is a great product.

bluesinthenight f.
NeuEve Silk

It works for vaginal atrophy!
I developed vaginal atrophy after chemotherapy for breast cancer. Because of my breast cancer, I’m unable to use estrogen suppositories. I had despaired of ever having painless sex with my husband until I tried NeuEve. It works! I’m now able to have sex without pain or using other lubricants. It’s nothing short of amazing. For those that complained of some discharge after use, I suggest using a panty liner. It’s completely worth it. Insertion is easy with or without an applicator, but I suggest remaining lying down completely still for at least 15 minutes after insertion. I’ve found that even pulling on my panties can cause it to slip out. I also find it’s best used when I go to bed, so it has all night to work its wonders. I’m 66 and have not been able to have painless sex in 15 years. This is a miracle. I plan to move on to the Silver Kit.

Amazon Customer

“This suppository is fantastic! I have had all the symptoms of menopause: dry, odor, and sexual pain. I have not had sex with my husband for years. The doctor prescribed vaginal estrogen suppositories, but they did not work for me. I used only 3 NeuEve’s suppositories and all my issues are gone. I feel great and can enjoy sex again. It has really saved my marriage.”

Amazon Customer

“I have been using the silver along with the cream…I love it! This has helped me more than anything that I have ever tried. I am switching to the gold in hopes that I will only have to use once per week. I will switch back to silver if it doesn’t work for me…..I had a hysterectomy nearly 20 years ago and have suffered from atrophy, BV, burning and itching associated with dryness. This all went away after one use!…I have tried vaginal estrogen, lubricants, vitamin E and nothing has helped until now. NeuEve is amazing…I cannot thank you enough!”

Amazon Customer

“Trust Me! This Really Works! I suffered from mild dryness and BV ever since I turned 50 now I’m 52. Estrogen patches and pills did not work for me but I was determined to find something since I am in a loving relationship with a 34 year old man! (need I say anymore…) I found this product 2 months ago and started with the silver since I was not having painful sex. I immediately noticed feeling lubricated from the inside out and I stayed that way for 5 days. Sex is beyond amazing and we make love twice a day sometimes more! So I decided to order the gold formula and had trouble receiving my package in fact I didn’t receive it. I called NeuEve customer service and who answers the phone? Dr. Chang herself the founder of this amazing product! She helped me track my product and when I still didn’t receive it she shipped me more free of charge. She also sent me a personal Email to check on me a few days ago to make sure I received it! Change your life and try this product as a nurse of 28 years, I have never experienced such a transformation ever!”

Amazon Customer

“I was really skeptical at first. I didn’t want to spend this much money and then if it did not work. But I was desperate. The doctors’ estrogen creams did not work anymore. I tried the hormone pellets and they worked great for about 4 years then it started back again. Nothing seemed to help. I was using the hormone cream daily and still no relief.
I went ahead and ordered the Gold. I wanted the strongest one. To my surprise, by the third day, all my symptoms were gone! I have used the product for 3 weeks now and am about to reorder. I use it once a week and the dryness, the itching, and the odor are gone! The only thing of course I wish the cost was less or they offered a discount if you got on auto-ship or bought a larger quantity.”

Amazon Customer

“I have used Neueve silk suppositories and cream for 2 months now and it has worked great! In the past, I have been on every estrogen product available with little relief. I finally have a sex life after 2 years and I am only 57 Thanks Dr. Chang another marriage saved.”

Angel J Guerra

Better than estrogen

IT REALLY WORKS! ITS AMAZING! I was really skeptical at first. I didn’t want to spend this much money and then if it did not work. But I was desperate. The doctors creams did not work anymore. I tried the hormone pellets and they worked great for about 4 years then it started back again. Nothing seemed to help. I was using the hormone cream daily and still no relief.
I went ahead and ordered the Gold. I wanted the strongest one. To my surprise, by the third day all my symptoms were gone! I have used the product for 3 weeks now and am about to reorder. I use it once a week and the dryness, the itching and the odor are gone! The only thing of course I wish the cost was less or they offered a discount if you got on autoship or bought a larger quantity.

Amazon Customer

Effective, better than prescription replacement estrogen medications that are wildly expensive
Reviewed in the United States on April 20, 2021
Verified Purchase
This is better than the expensive doctor prescribed estrogen replacements like Premarin and other estrogen products. Very pleased and don’t need prescription. Safe ingredients. Works!

About the author

Dr. Renjie Chang's medical and pharmaceutical experience:
- OB-GYN in the Peking Union Hospital in China
- a faculty member of OB-GYN at University of Oklahoma Health Sciences Center
- drug developer at the Abbott Laboratories in Chicago
- Founder of Lavax, Inc, where she developed an innovative vaginal microbicide for preventing sexually transmitted disease with grants from NIH and Gates Foundation
- Founder of NeuEve, an all-natural women's health company

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