Worldwide, breast cancer is the most common invasive cancer in women. The United States has the highest annual incidence in the world, about 125 per 100,000. The lifetime risk is 1 in 8 women (1).
About 90% of women today can survive breast cancer after treatment (2). But, many survivors must endure a significant side effect of antiestrogen therapy. It is vaginal atrophy―with vaginal dryness, painful sex, and sexual dysfunction (3).
Vaginal atrophy is not a disease, but an aging outcome. When women get older, their vaginal tissue becomes atrophic. But, breast cancer treatment can result in an early onset of the aging outcome in younger women. The causes are chemotherapy and the artificial suppression of estrogen (4).
Worse than antiestrogen therapy for breast cancer is pelvic radiation therapy. Women with the following cancers may receive this therapy:
- cervical cancer
- womb (endometrial) cancer
- vaginal cancer
- vulval cancer
- bladder cancer
- rectal cancer
- anal cancer
- lymphoma in the pelvic area
Antiestrogen therapy shrinks vaginal tissue by nutrient starvation. There are no physical injuries. Many treatment methods can reverse this type of atrophy. These include NeuEve and MonaLisa Touch. But, radiation therapy kills cancer cells by damaging their DNA. Cancer cells with DNA damage stop dividing and die. A problem of radiation therapy is collateral damages to adjacent tissues. It is difficult to repair radiation-induced vaginal atrophy.
To date, NeuEve is the only product that has showed an effect in relieving vaginal atrophy in women with pelvic radiation therapy.
Estrogen supports woman’s reproductive tissues
The female hormone estrogen supports the development of a woman’s reproductive tissues. These tissues include breasts, ovaries, the uterus, and the vagina (5). A healthy reproductive-aged woman has a high level of estrogen. Her vaginal lining is thick and well developed (6).
After menopause, estrogen declines, but not diminished
After a woman reaches menopause, the production of estrogen in the ovaries declines (7). Yet, the estrogen level does not reduce. Adrenal glands and fat cells also produce estrogen (8). As a result, after menopause, a healthy woman can still produce a low level of estrogen. It can still maintain the wellbeing of reproductive tissues and bone health (9). The production of estrogen reduces with aging, but it does not stop even the woman is 80 years old.
Breast cancer treatment
Tamoxifen works by competing with estrogen for receptors in breast cancer cells. This suppresses cancer growth. Yet, it can block the estrogen effect on normal cells, such as the cells in the vaginal tissue.
Aromatase, also called estrogen synthase, is an enzyme responsible to produce estrogen. It is in tissues that produce estrogen. These include ovaries, adrenal glands, and fat cells.
When women are on Tamoxifen or aromatase inhibitors, estrogen loses effect. As a result, many side effects associated with declining estrogen may appear. These include osteoporosis, joint disorders, and vaginal atrophy.
What are the symptoms of vaginal atrophy?
Vaginal atrophy may cause a range of symptoms. These include vaginal dryness, painful intercourse, itching, and burning. Vaginal atrophy reduces tissue resistance against infections. Recurrent bacterial vaginosis (BV) and chronic urinary tract infections (UTIs) often occur (11).
Vaginal atrophy in healthy women vs. breast cancer survivors
In healthy women, vaginal atrophy may develop after menopause. The cause is the aging-related reduction of estrogen. The estrogen level is only decreased, but not diminished. Even a woman of 80 years old can still produce a low level of estrogen. Both estrogen supplementation and non-estrogen methods can relieve vaginal atrophy. Recovery is often fast and achievable.
In breast cancer survivors, vaginal atrophy is often more severe (12). The cause is artificial estrogen suppression. As a result, women’s internal estrogen is ineffective. Or its production is completely shut off. Estrogen supplementation cannot be used to treat vaginal atrophy. The only options are non-estrogen methods. Recovery is often slow and difficult.
What are complications of vaginal atrophy?
Vaginal atrophy increases your risk of:
Vaginal infections, especially BV. The thinning of the vaginal skin reduces the normal vaginal cell exfoliation. The vaginal acid balance changes to a higher pH. These changes in the vagina make vaginal infections more likely.
Urinary tract infections (UTIs). Reduced estrogen can cause the thinning of the inner skin of the bladder. It also increases the bacterial load in the vagina. It is a reservoir for bacteria to cause chronic UTIs. You might experience increased frequency or urgency of urination or burn with urination. Some women experience more urinary tract infections or urine leakage (incontinence).
Treatment options for painful sex in breast cancer survivors
Estrogen promotes the recurrence of breast cancer. Its supplement is not an option for breast cancer survivors. The only treatment options are non-estrogen methods. These include three categories:
1. Energy-based devices
Several energy-based devices are available in selected OG/GYN clinics. Doctors use these devices to perform intravaginal treatment for “rejuvenation” purposes. They use radiofrequency or laser to generate heat or micro-injuries in deep tissue. Micro injuries can trigger a “wound-healing” effect. New tissues may grow up during the healing process. Would-healing helps regrow the atrophied vaginal tissue.
The brand names of these devices include:
Since these devices do not use estrogen, many breast cancer survivors have tried them. While these treatments can provide good relief, there are some problems.
One problem is accessibility. These devices are high-priced heavy-duty equipment that is not available. You cannot buy one and do a self-treatment by yourself. You need to visit an OB/GYN clinic where it is available. Not all clinics in your area have one.
Another problem is the cost. For one set of treatments, it costs about $2,500. Insurance does not cover it (13). Many breast cancer survivors cannot afford it.
The third problem is the short-lived effect. They all claim that one treatment can provide relief of one year (14). This may be for a woman with mild to moderate vaginal atrophy. Yet, many breast cancer survivors have severe vaginal atrophy. They reported that the effect only lasted for 3 months. After 3 months, atrophy returned, and they would need a second set of treatments. Thus, for the effect to last about one year, they may need many treatments. This further jack up the cost.
The US Food and Drug Administration (FDA) issued a warning letter about these devices:
2. Nutritional supplements
Menopause causes osteoporosis due to the reduction of estrogen (15). Estrogen supplement can reverse osteoporosis, but it has a cancer risk. A safer method to reverse osteoporosis is taking calcium and vitamin D3 and K2 pills (16). This method is nutritional supplements. To date, millions of post-menopausal women are doing that. They have achieved overwhelming success.
Likewise, nutritional supplements can relieve vaginal atrophy. This method includes two categories: topical nourishment and dietary supplement.
2A. Topical nourishment
When estrogen declines, nutrients allocated to the vagina reduce. Nutrient starvation causes it to become atrophied. Thus, delivering either estrogen or nutrients to the vagina can reverse vaginal atrophy.
NeuEve products are for self-treatment of vaginal atrophy. They deliver skin-rejuvenating nutrients, like vitamins, minerals, and fatty acids. The nutrients promote the growth of collagen and elastin fibers in the vaginal tissue (17).
Topical nourishment can enrich these fibers. It makes the thin skin to grow thicker, more elastic, and resilient. The process is like putting cream on the face to smooth wrinkles.
NeuEve has three levels of suppositories and one cream. Cancer survivors can start with NeuEve Silk suppository and vulva balm cream.
The method is to insert a suppository in to the vagina once every 4 days. Apply the NeuEve Cream a tiny bit (a dime size) daily on the external vulva. To reverse vaginal atrophy caused by breast cancer treatment takes time. It may take 1-4 months depending on how severe the atrophy is.
2B. Dietary supplement
Topical nourishment can be effective due to direct skin absorption. Yet, if the atrophy is severe, only limited nutrients can reach deep tissues from the skin surface. Combining with dietary supplements can work better. The dietary supplement pills include:
a) One A Day Multivitamin W/Minerals Tablet. The multivitamin with minerals tablet can help prevent deficiency of these nutrients. Some are for women over 50. If you are not taking this pill, we recommend that you do. Even if you are taking it now, we recommend that you take more supplements detailed as follows.
b) Calcium, magnesium, zinc, and vitamins D3+K2. These are the most important supplements that you need to take at this age. Without vitamins D3 and K2, calcium may not absorb well. Additionally, vitamin D correlates to urogenital health in older women. Calcium is essential not only for bones but also for mucus gland secretion. If osteoporosis is not managed, the mucus gland can dry out and the vagina atrophied. The fact that you have severe vaginal dryness and atrophy indicates severe osteoporosis. Please pay special attention to this matter before getting unexpected fractures!!!!!!!!!
c) Fish oil (or flaxseed oil) for omega-3. if you do not like fish, you can take flaxseed oil pills instead. Also, eat a lot of fish if you like to eat fish. Fish provides omega-3 and also collagen proteins that support your skin.
d)Sea buckthorn oil for omega-7. This fatty acid helps you to revive mucus glands and keep moisture in the oral cavity, eyes, and vagina. You can find this supplement on https://www.neueve.com/sea_buckthorn
e) Collagen and/or gelatin. Collagen is a major protein in your body, and gelatin is a degraded form of collagen. Thus, they have identical nutritional values and may both improve your skin health. Due to aging, collagen synthesis reduces. A common sign is the atrophy of skin (wrinkles) and mucosa (like vaginal atrophy). Thus, supplementing collagen/gelatin can help make the atrophied vaginal lining stronger. You can take collagen powder or pills. Or, you can eat collagen in various foods, like Jello, Gummy bear, pork rind, or vegan collagen. For enough supplement, it is important to keep a minimum daily dosage of 2.5-15 grams of collagen/gelatin.
3. Dilation exercise
While you are using NeuEve Silk and Cream, you can do the dilation exercise to speed up the healing process.
Dilation is another self-treatment method for vaginal atrophy (25).
You might have seen handicapped people sitting in a wheelchair with thin legs. Their leg muscles shrink after disusing. If one day they can stand up, they must do walking exercises to grow back their leg muscles. This means that exercise is important and useful.
Stretching the skin promotes its elasticity and durability. It promotes the synthesis of elastin and collagen fibers. Dilation with a set of dilators can help strengthen weak skin. Dilation exercise reduces vaginal atrophy in breast cancer survivors (26). You can find a set of dilators from this link www.neueve.com/dilators.
Once you are on the product webpage, you can click the “Learn More” button. It will lead you to the VuvaTech website.
We recommend magnetic dilators. Magnets in the dilator may help stimulate the atrophied tissue to grow thicker (27).
You can start from a small-sized dilator and do dilations twice a day (morning and evening). Each time 20 minutes. After 1-2 weeks, you may move up a size.
Once you move up to the largest size without pain, your skin will be strong enough. It may endure the stretch caused by sex. Your vaginal atrophy will heal. You may no longer experience the tearing and pain during intercourse.
It is understandable that one may wish to move up the sizes quickly or to try the largest sized dilator first to get a more rapid recovery. However, recovery of vaginal atrophy is a slow process. Moving up the dilator sizes too quickly or skipping sizes can cause overstretching injuries and may be counterproductive. Please do not skip the sizes and try the largest dilator first. Please be patient and do the exercise with a stepwise increment to avoid possible overstretching injuries.
Physically, dilation exercise is like sexual intercourse. The penetration movement can mobilize bacteria normally on the skin into the bladder to cause UTI. You will need to pee immediately after each exercise to prevent UTI. Urination can flush out any bacteria that entered the bladder during the dilation exercise. Therefore, drinking a lot of water before exercise helps build up the urinating flushing pressure and prevent UTI.
In summary, NeuEve Silk, Cream, dietary supplements, and dilation can help cancer survivors find relief. Yet, the recovery of vaginal atrophy may take time. Please be patient to allow these methods to work.
Can women with active cancer use NeuEve?
NeuEve is all-natural, hormone-free, herbs-free, and yam-free. It works by providing essential nutrients to the atrophied vaginal soft tissue. Essential nutrients include vitamins and minerals. Without these in the diet humans cannot survive. The difference is that NeuEve delivers them to the atrophied vaginal tissue. It is like a facial cream for stopping wrinkles on the face (atrophy of the skin). Thus, NeuEve is safe.
Since NeuEve is hormone-free, it does not interfere with breast cancer treatment. But, we do not recommend women with active breast cancer to use NeuEve. Due to recent advancements in medicine, the breast cancer cure rate has improved a lot, but it is not yet 100% (28). If the cancer is not completely cured, other things that the patient has used might be blamed.
If you have active cancer, you should focus on cancer treatment first. Once your cancer is in remission, you can use NeuEve without any worries.
Disclaimer: This article is for information purposes only. It is about natural products, nutrients, and/or methods for managing aging-related discomforts (not diseases). It is not medical advice for the treatment of any diseases.
Customer reviews on NeuEve from cancer survivors
March 14, 2021
I have only been using this product for a few months now. I cannot use hormone treatment because of breast cancer. Very happy with this product and being all-natural. It has helped with the vaginal atrophy and I have not had a urinary tract infection since I started using it. Has helped with the dryness also.
August 20, 2020
I ordered these for my mother-in-law, and this is what she has to say:
“My urologist told me to get these! I was having constant UTI’s for the past few years, I am 58 and after being diagnosed with breast cancer at 49 and then being told to have my ovaries removed too. I had everything taken out except my vagina. After that, it was much too painful for any of that kind of fun!
I do believe in miracles and maybe your product will make it possible again!!!
Your product has made me feel so much better! I do not have the horrible feeling of getting a UTI anymore or any dryness and not one UTI since I started!!! Which is huge!!! So, thank you for caring enough for women’s health to make such a wonderful product!!!
This is such a hard subject to discuss no one talks about it and not something I normally would but I think I need to tell you it is working so far! The price is high, but I will just have to save somewhere else!!!
It has been about 6 weeks since I started, and I can feel the walls of my vagina are starting to soften which had hardened (I have even had surgery to clip scar tissue that was like rings closing my vagina) I didn’t even know if I could get one of your suppositories in!!! But had no problems!!!
I felt I needed to write this because it is the first thing that has worked!!! I am not sure I would have tried this because of the price if my doctor had not told me to. I think if you were to give some samples to doctors so more women could try them. More women would be using them even if they tried them once they could see how they could change their lives too!!!
Please know you really are helping women like me and I just have to say Thank you again!!!”
Definitely helped with my problem
Reviewed in the United States on May 12, 2019
I am 59 years old and the last couple of years have been more torture than pleasure when it came to intimacy. I think my husband thought I no longer found him attractive- or worse. The truth is that sex became so painful I began to dread it.
I have breast cancer in my family and longed for something to help. I stumbled upon these with an internet search and the reviews were great! I noticed an improvement after the first suppository. I am on my third month now. I started with wild, then silver, and recently have purchased gold.
I did not give 5 stars because it is pricey and while the scent is not offensive, I do not really care for it. Also, after three months, I cannot say I am pain-free exactly, but I have seen a major improvement in my sex life.
August 15, 2018
Breast cancer survivors love NeuEve.
“I just had to tell you, please let the amazing doctor who developed this product know that it has truly changed my life. Breast cancer with chemo, then forced oophorectomy (darn ovaries would not stop making estrogen and I can’t take tamoxifen), and now anastrozole. This caused severe vaginal atrophy and very painful sex. I tried Mona Lisa Touch which worked so so and only temporarily, and ThermiVa which did nothing. Your product has changed the tissue and dramatically decreased the pain. I have to stick with Level 1 though because Level 2 doesn’t work as well. I have shared NeuEve with many friends and it has changed their lives too!! Thank you!!”
Finally, this WORKS
Reviewed in the United States on March 3, 2017
I have used NeuEve silk suppositories and cream for 2 months now and it has worked great! In the past, I have been on every estrogen product available with little relief. I finally have a sex life after 2 years and I am only 57. Thanks, Dr. Chang, another marriage saved
It works for vaginal atrophy!
Reviewed in the United States on September 15, 2017
I developed vaginal atrophy after chemotherapy for breast cancer. Because of my breast cancer, I am unable to use estrogen suppositories. I had despaired of ever having painless sex with my husband until I tried NeuEve. It works!
I am now able to have sex without pain or using other lubricants. It is nothing short of amazing. For those that complained of some discharge after use, I suggest using a panty liner. It is completely worth it. Insertion is easy with or without an applicator, but I suggest remaining lying down completely still for at least 15 minutes after insertion.
I have found that even pulling on my panties can cause it to slip out. I also find it is best used when I go to bed, so it has all night to work its wonders. I am 66 and have not been able to have painless sex in 15 years. This is a miracle. I plan to move on to the Silver Kit.
Reviewed in the United States on February 7, 2017
I am a young cancer survivor that was forced into menopause early from my cancer treatments. This is the only product that has worked long term for me.
I struggled with BV issues for some time and obviously vaginal atrophy from pelvic radiation, since using this product I have not had one single reoccurrence of BV. I have since recommended this product to a few of my friends all of whom are either pre-or post-menopausal with similar issues (odd odor, less natural lubrication) and they all seem to love it and recommend it.
I would say initially I was skeptical; I have been using this for about 6 months and my honest opinion is that this product is exactly what the packaging states. Please keep in mind I produce no natural hormones and have been in hormone replacement therapy for 5 years, nothing has worked as well as this product. It is safe, effective, and works quickly.
Marianne F. Sanders
Reviewed in the United States on March 14, 2016
These have helped me a great deal. I am an estrogen-positive breast cancer survivor so I could no longer use prescription estrogen creams to stop my vaginal atrophy. This has helped alleviate pain wonderfully well.
March 4, 2016
Helped my UTIs
I am a breast cancer survivor with chronic UTIs. I was told that they were caused by vaginal atrophy due to loss of estrogen, but I cannot use any estrogen due to the cancer diagnosis. I tried this product to see if it would help, and to my amazement, it did!
The atrophy was causing inflammation in my urinary tract, and the inflammation was attracting bacteria, generating an infection. I had one almost constantly for 3 years.
Literally the first time I used the product I could see and feel a difference. I have not had a UTI since starting this product. The rest of the benefits of no atrophy are great, but I am so grateful to have found this helpful product for my urinary tract. Hopefully, other sufferers will find the same result.
Reviewed in the United States on July 14, 2015
I have been using the Silk formula for about five months. I had post-menopausal vaginal dryness which was contributing to repeated UTI’s. The dry atmosphere promoted bacterial growth.
In addition, I had extreme vulvar pain (vulvodynia) and every remedy I tried felt as though I was applying acid. I was desperate after three rounds of antibiotics in four months and still had horrible burning pain.
My doctor prescribed hormone cream but I was reluctant to use it since there is a history of breast cancer in my family.
While desperately searching online (sitting on a cold compress at the time) I came across NeuEve and ordered immediately, both the silk formula and the cream to start with. I experienced immediate relief, using the cream daily for about the first month and the suppositories twice weekly as directed. No more UTI’s!
Immediate relief and freedom from the burning! I saw my GYN for the yearly checkup two weeks ago and he is very happy that the dryness has resolved. He thanked me for the information about NeuEve and said that he is pleased to have a safe alternative to the hormone cream to recommend to patients.
I am just about to try the Silver formula. I will never be without NeuEve! Dr. Chang is obviously very knowledgeable about this problem to have created such an effective treatment. I will be forever grateful that she did!
Surviving Radiation Therapy with NeuEve
Reviewed in the United States on May 5, 2015
“Thank you, Dr. Chang. And thank you for the greatest product ever. I had uterine cancer and underwent radiation therapy. NeuEve has been a life-changer.”
Bicycling painful and it was making me miserable although I am ..
Reviewed in the United States on February 26, 2015
I am a young sixty-year-old woman and breast cancer survivor. My kids call me sixty and sexy, but I was not feeling sexy.
I was extremely sensitive and tender to the point that my clothes chaffed me, sitting was uncomfortable, bicycling painful and it was making me miserable although I am a happy individual.
I had used estriol cream with little effect. My woman’s health doctors dismayed that the gynecological world was focused on the reproductive years and women beyond that were ignored.
After being told I should use zinc oxide to heal the chaffing, I desperately and thankfully sought help on the internet and discovered NeuEve and Dr. Chang.
I am only using less than a week and I am the most comfortable I have been in years. I just subscribed and am thrilled to have regained my sexual health. Thank you, Dr. Chang!
A Life-Changing Product!
Reviewed in the United States on October 20, 2014
Just returned from a mini-vacation with my boyfriend, had to write!
After over a year of post-menopausal dryness, painful sex, and bleeding after intercourse, I was desperate for a solution. I am uninsured, so I cannot use prescription estrogen because it is too expensive. Nothing I tried over the counter worked well, especially for the pain and bleeding.
I used one Silver suppository the night before our trip. When I got up to go to the bathroom during the night, I could literally feel it working! It is hard to describe, but it felt tingly like my tissue was plumping and coming back to life.
Well, the next night when we were on vacation was the first time in over a year, I had sex that was pain-free! We used a glycerin-based lubricant and had a wonderful night together. We were amazed! But I did experience bleeding afterward, as usual.
My boyfriend was being a good sport about the bleeding, so I used a second suppository the next morning before we started our tour. Well, that night there was no pain OR bleeding…… Nothing! I felt so liberated. No more towels or sanitary pads, I have my dignity and my sexuality back!
I am spreading the word to all my friends. Those who are great cancer survivors will be especially excited to try NeuEve! It was truly life-changing for me, and I cannot thank you enough for this wonderful product!